Hepatocytes comprise 80% of liver cells and emainder is made up of sinusoidal endothelial cells (10%),bile duct endothelial cells(1%)andcells of the immune system(9%).Endothelial cells line the hepatic sinusoids,which constitute anetwork of capillary vessels that differ from other capillary beds in the body in that there is no basement membrane.The endothelial cells have gaps between them (fenestrae) of about 0.1 micron in diameter allowing free flow of fluid and particulate matter to the hepatocytes.
Individual hepatocytes are separated from the leaky endothelial lining of the sinusoide by the space of Disse,which contains non-parenchymal cells called stellate cells Stellate cells store vitamin A and play an importent part in regulating liver blood flow.They differentiate into my ofibroblasts in response to cytokines produced by kupffer cells and hepatocytes following liver injury,
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